The ISS National Lab is a U.S. government-funded national laboratory located on the International Space Station (ISS). Managed by the Center for the Advancement of Science in Space (CASIS) under a Cooperative Agreement with NASA, it facilitates access to the ISS for U.S. researchers from various sectors to conduct research and technology development in microgravity. The ISS National Lab supports a wide range of research, including life sciences, physical sciences, technology development, and remote sensing, with the goal of improving life on Earth and fostering a sustainable low Earth orbit (LEO) economy, with partners including NASA, academic institutions, government agencies, and commercial companies.
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A record-breaking 114 ISS National Lab-sponsored payloads were delivered to the orbiting laboratory in 2025.
2025 marked the launch of the Orbital Edge Accelerator, the first accelerator program developed by the ISS National Lab.
More than 75 peer-reviewed articles related to ISS National Lab-sponsored research were published in the fiscal year from October 1, 2024, through September 30, 2025.
Margaritaville unveiled a mission patch in support of the ISS National Lab, with 100% of proceeds donated to CASIS for research funding.
The ISS National Laboratory was established through an act of U.S. Congress.
The ISS National Lab was created by Congress to enable researchers to build a robust market in low Earth orbit by leveraging the unique environment of space.
Over the past 14 years, the ISS National Lab has conducted research into cancer, neurodegenerative diseases, aging, manufacturing done in space, and communications technology.
CASIS supports education programs for students of all ages involving the ISS National Lab.
The ISS National Lab has supported more than 630 peer-reviewed studies that establish groundwork for future applications of significant value for humanity.
CASIS has managed the ISS National Lab since 2011.
NASA has entrusted CASIS with managing the ISS National Lab for nearly 14 years.
In 2024, the ISS National Lab partnered with NASA's Biological and Physical Sciences Division to award a total of $7 million to fund five projects intended to advance cancer research.
Private firms account for about 60% of the more than 940 scientific payloads processed by the ISS National Lab.
Congress should allow NASA and the ISS National Lab to allocate funds for microgravity research on any US platform meeting the requirements.
The HTV-X is transporting more than 20 projects sponsored by the ISS National Lab.
By testing Stirling technology on the ISS National Lab, Intuitive Machines aims to raise its readiness level from prototype to space-flown.
The Stirling Technology spAce Research experimenT (START) is a flight experiment designed to demonstrate Stirling power conversion technology in space aboard the ISS National Laboratory.
ASTROBEAT is an innovative experiment sponsored by the ISS National Laboratory to advance spacecraft repairs using cold welding.
Redwire is partnering with NASA and the ISS National Lab to operate the PIL-BOX platform.
The Notre Dame microgravity biosensor project builds on the team’s prior ISS National Laboratory-sponsored research and could lead to new sensor technology for detecting early cancer markers in blood.